Another Culprit In Breast Cancer
BRCA1 has been getting a lot
of press because mutations in the gene are responsible for about 3 percent
of all cases of breast cancer.
But there might be an even worse villain. Researchers from the Howard
Hughes Medical Institute at Baylor College of Medicine have identified a
protein that triggers the mouse version of the BRCA1 protein to initiate the
repair of damaged DNA.
They say that mutations in the human gene that produces this trigger
protein are likely to be responsible for more instances of breast cancer
than BRCA1 mutations.
The discovery of the trigger protein, made by a gene called ATM, suggests
that malfunctions in BRCA1 and ATM combined may account for nearly 10
percent of all breast cancers, said lead study author and HHMI investigator
The results were reported in the journal Science.